Deschamps, who has led France to back-to-back World Cup finals, has made a few surprise calls ahead of his final major tournament as head coach.
There is no place in the squad Real Madrid midfielder Eduardo Camavinga or Tottenham's Randal Kolo Muani – both of whom were involved in 2022.
PSG goalkeeper Lucas Chevalier also misses out, with uncapped Lens goalkeeper Robin Risser joining Brice Samba as back-up to Mike Maignan.
Liverpool's Huge Ekitike, who suffered a season-ending Achilles injury in April, is a notable, but expected, absentee.
"It's a squad. Not necessarily the 26 best players. It's about balance and how the team comes together," Deschamps told French TV channel TF1.
"I can imagine how disappointed [Camavinga] must be. He's coming off a tough season where he didn't play as much and suffered injuries. [But] I've got decisions to make and a squad to put together."
France will begin their campaign against Senegal in New Jersey on 16 June, with further Group I matches against Iraq (22 June) and Norway (26 June).
Goalkeepers: Mike Maignan (AC Milan), Robin Risser (Lens), Brice Samba (Rennes)
Defenders: Lucas Digne (Aston Villa), Malo Gusto (Chelsea), Lucas Hernandez (Paris St-Germain), Theo Hernandez (Al Hilal), Ibrahima Konate (Liverpool), Maxence Lacroix (Crystal Palace), Jules Kounde (Barcelona), William Saliba (Arsenal), Dayot Upamenaco (Bayern Munich)
Midfielders: N'Golo Kante (Fenerbache), Manu Kone (Roma), Adrien Rabiot (AC Milan), Aurelien Tchouameni (Real Madrid), Warren Zaire-Emery (Paris St-Germain)
Forwards: Maghnes Akliouche (Monaco), Bradley Barcola (Paris St-Germain), Rayan Cherki (Man City), Ousmane Dembele (Paris St-Germain), Desire Doue (Paris St-Germain), Michael Olise (Bayern Munich), Kylian Mbappe (Real Madrid), Jean-Phillipe Mateta (Crystal Palace), Marcus Thuram (Inter Milan)
Extracted and lightly reformatted for readability. · Source: pt