Galal Yafai's bout with unified flyweight world champion Ricardo Sandoval has been postponed after the Briton sustained an injury in training.
It is the second time the 6 June card in Sheffield has lost its headliner, after British WBC light-welterweight champion Dalton Smith pulled out of his defence against Alberto Puello through injury.
Yafai, 33, has not fought since losing to Francisco Rodriguez Jr in June - although the result was overturned to a no-contest after the Mexican failed a drugs test.
The Birmingham fighter, who won gold at the Tokyo Olympics in 2021, is undefeated in 10 fights as a professional - with seven of his nine victories coming inside the distance.
Next month's event at Utilita Arena will still go ahead, with Josh Padley's European super-featherweight title defence against Aqib Fiaz now topping the bill.
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